Progesterone prophylaxis?

Trial protocol OPPTIMUM– Does progesterone prophylaxis for the prevention of preterm labour improve outcome?

BACKGROUND Preterm birth is a global problem, with a prevalence of 8 to 12% depending on location. Several large trials and systematic reviews have shown progestogens to be effective in preventing or delaying preterm birth in selected high risk women with a singleton pregnancy (including those with a short cervix or previous preterm birth). Although an improvement in short term neonatal outcome...

Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial

BACKGROUND Progesterone administration has been shown to reduce the risk of preterm birth and neonatal morbidity in women at high risk, but there is uncertainty about longer term effects on the child. METHODS We did a double-blind, randomised, placebo-controlled trial of vaginal progesterone, 200 mg daily taken from 22-24 to 34 weeks of gestation, on pregnancy and infant outcomes in women at ...

Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial double-blind trial

Antibiotic Prophylaxis and Preventing Postpartum Infection

بحث بر روی کاربرد پروفیلاکسی آنتی بیوتیک ها در مامائی، در اواخر سال ۱۹۴۰ شروع شد و تجویز پروفیلاکسی پنی سیلین به تمام بیماران در لیبر باعث کاهش شیوع تب از ۶/۳ به ۴/۲٪ می شود. ولی هرگز آنتی بیوتیک پروفیلاکسی بطور عمومی مورد قبول واقع نشد. بدلیل اینکه اولا شیوع عمومی عفونت، پائین است و عفونتها بندرت شدید می شوند، بطوریکه بیش از ۹۵ تا ۹۷ بیماران احتیاج به آنتی بیوتیک پیدا نمی کنند. شاید، تجویز غیر...

INFORMATIONAL GUIDE PROGESTERONE METABOLITES PREMENOPAUSE Urinary Progesterone Metabolites in Premenopausal Women Not Supplementing with Progesterone

The urinary progestogen metabolites included in our profiles encompass the primary urinary metabolite, pregnanediol (Pgdiol), and four other more minor metabolites that belong to the pregnane (Allopregnanolone, Allo-pregnanediol) and pregnene (3α-dihydroprogesterone, 20α-dihydroprogesterone) categories. In postmenopausal women the level of pregnanediol is expected to be much lower than in preme...